27 Nov 2023 - 27 Nov 2023 4:00 pm - 5:00 pm Online Event

How can in silico methods support the derivation of safety limits?

A SaferWorldbyDesign Webinar and Discussion

In silico methods can aid chemical safety assessment by providing a knowledge-based and convenient prediction of chemical toxicity. Currently, in silico predictions are extensively used to support hazard identification (for example: yes/no prediction of bacterial mutagenicity). Conversely, integration of computational models in regulatory frameworks to establish quantitative safety limits remains still challenging. The aim of the talk is to discuss ways to apply in silico methodologies in the context of safety limits derivation for regulatory purposes. Generally, each application field (e.g., occupational toxicology, extractables, leachables, non-genotoxic impurities) follows specific workflows to integrate in silico methods (using class assignment and/or read-across approaches) in the chemical assessment.

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